[Andreas Jung]
That's what I have. My box (vmware) is pretty much a new XP installation with no old Python installation except a local Zope installation which its own Python (but not registered anywhere in the registry).
[Tim Peters]
I'm not sure what local Zope installation (LZI) means. Running a Windows Zope installer always writes registry keys, so if your LZI was created by running a Windows Zope installer, you do have stuff in the registry pointing at it. I don't know why that would matter, but maybe it does.
[Andreas Jung]
So what would be the solution to get b2 running without touching this installation (which I need for my work)?
I don't know -- I'm still not even sure what LZI means to you. Resolution probably depends on some detail I wouldn't be able to guess, and I have no experience trying to run more than one installed Zope on a Windows box. Anyone else? Whatever LZI is, if it were my box I'd uninstall it, and reinstall it later (the uninstall process would leave its Zope instance home alone).