[Zope] ZODB limits

I'm developing an intranet document management system with Zope/Plone and I'm concerned about the capabilities of ZODB. The system is going to store many thousands of large files, so the Data.fs is very likely to grow up to tens of GB. I'm wondering if ZODB can handle such amount of data in its standard implementation (using Data.fs). I investigated several alternatives, including ApeLib/Dbtab, but they don't seem to work out of the box with Plone (while thay do in ZMI). Is somebody aware of **fully-tested, real-world** applications with multi-GB storage or, in other words, should I stay with ZODB or search for alternatives? Thanks Alessio Beltrame