[Zope] Question: Virtual Site Hosting on Zope

I know this will be an easy question for this mailing list... Is there generally considered to be a 'best way' of doing Virtual Site Hosting on Zope? I have skimmed some HOWTOs on www.zope.org, but I am afraid the material may be a bit dated and a 'better way' may be generally known. Any help would be appreciated! Mike