I can not see how zope hosting in itself will ever pay for its cost.
In the case of a fully automated setup + administration + maintaining it would be possible, and that is what we should consider to build.
As for automated hosting, I'm hosted by imeme.net, and as far as I can tell, it is fully automated : when I subscribed, I got my own jailed environement setup, with zope installed with apache, and I have access to a "client area" where I can add domains and email accounts in seconds. Then in my zope I have a modified vhostmonster which simply asks for domain name -> zope path. I can setup a site using this tool in 1 minute for my own customers without the need to ask the hosting support. There is no extra fee for additional domains. Actually it's cheaper than any other solution I previously used. I hope they will keep it like this :-) Philippe