[Zope] zopespeed

hi there I'm having some trouble with a site, which is too slow. I tried the httpcachemanager and the ramcachmanager. unfortunately I'm not able to cache my own zclasses (they are not listed). I use quite a lot of aquisition and a lot of python scripts with "again" a lot of loops. I'm using Zope 2.4.3 on a MacOSX machine. can you give me some performance tips. thank you for any help. kind regards daniel