[Zope] Optimization of Speed, Performance

I have read over all of the benchmarking and performance figures for Zope but has anyone written (thought about, scribbled notes) something about how to optimize a Zope installation? Thinks that need some consideration. - Memory Management (increase, decrease) - Cache Flushing - Threads? I am running ZServer by itself and it is fast, but how can I get it to go FASTER? Thanks, JMA