Thanks to those that responded off-list to my original query, but I'm still having no joy whatsoever in getting Zope to properly handle requests proxied to it from Apache. My Apache configuration is: <VirtualHost 10.0.0.2> ServerName www.test.com ServerAlias test.com RewriteEngine On RewriteLog "/var/log/httpd/rewrite_log" RewriteLogLevel 9 RewriteRule ^/(.*) http://localhost:8080/VirtualHostBase/http/test.com:80/VirtualHostRoot/$1 [L,P] </VirtualHost> (RewriteRule directive shown wrapped over three lines.) test.com is defined as a zone on my local name server pointing to 10.0.0.2. I have a VirtualHostMonster in the Zope's root folder with no mappings defined there. Also in the root folder is a folder "test.com" with the default DTML document index_html. When a request is made to www.test.com, Zope intercepts it but displays the (acquired?) content from the root folder's index_html. Snippets from the error_log show this: TraversalRequestNameStack [] VirtualRootPhysicalPath ('',) URL 'http://test.com:8080/%241' SERVER_URL 'http://test.com:8080' URL0 http://test.com:8080/%241 URL1 http://test.com:8080 BASE0 http://test.com:8080 BASE1 http://test.com:8080 BASE2 http://test.com:8080/%241 (No idea what the %241 implies, but it's there in the error log) PATH_INFO '/VirtualHostBase/http/test.com:8080/VirtualHostRoot/$1' HTTP_HOST '127.0.0.1:8080' REQUEST_METHOD 'GET' PATH_TRANSLATED '/VirtualHostBase/http/test.com:8080/VirtualHostRoot/$1' The "/$1" on the end of PATH_INFO and PATH_TRANSLATED would suggest to my naive eyes that Zope isn't properly mapping the URL to a local resource, but that's just conjecture on my part. VirtualRootPhysicalPath also looks a little suspect. If I make an explicit request for http://10.0.0.2:8080/VirtualHostBase/http/test.com:80/VirtualHostRoot/ (as suggested by an off-list response), then again, the root folder's index_html is returned, not that of test.com. Requests to 127.0.0.1 as opposed to 10.0.0.2 generate the same result. Muchos kudos to anyone who can shed some light! mh