[Zope] how to dynamically define a ZMySQL connection

Does anybody know how I could dynamically edit an existing ZMySQL connection object, within a HotFix product or some python based method? Reason I ask is sometimes the mysql server will move to a different machine. I'd prefer not to login to Zope and make the change, but rather edit some external file that defines the server name. If there is a way to access the various Data.fs objects from a HotFix type product, I think this would be possible. Thanks, Albert