Here is what finally worked for me (under Win98). To use Zope with a MySQL database under Windows, do the following. 1. download the following packages. the MySQL for Windows installer, version 3.23.39 (or newer) at http://www.mysql.com/downloads/. Andy Dustman's Zope database adapter for MySQL, version 2.0.8 at http://www.zope.org/Members/adustman/Products/ZMySQLDA the python extensions package for MySQL, version 0.9.0 (or newer) at http://prdownloads.sourceforge.net/mysql-python/ Isaac Salsberg's BuildMySQLDA package at http://www.zope.org/Members/isalsberg/MySQLDA/BuildMySQLDA.zip 2. Install MySQL. 3. Decompress the ZMySQLDA package in Zope's root directory. 4. Decompress the mysql-python package to a temp directory. From this temp directory, move the following files to the <Zope_root>\bin directory. _mysql_exceptions.py CompatMysqldb.py The whole directory MySQLdb 5. Decompress the BuildMySQLDA package and move _mysql.dll to the <Zope_root>\bin directory. Restart Zope and you should be able to add a new "ZMySQL DA Connection".