sean.upton@uniontrib.com writes:

However, doesn't Python impose some sort of limit as well? Anyone have a number? Does this depend on the architecture of the machine (i.e. 64 vs. 32 bit)? Python does not impose a serious limit (independent on the word size). If the C library and the underlying operating system can handle files larger than 2 GB, then Python can do, too.

If you upgrade your C library for large file support, you may need to reconfigure and regenerate Python as the file access interfaces are not binary compatible. Dieter