Can anybody advise how to run multiple web sites using zope on one server, currently I have to type http://www.cbsolutions.co.uk:8080 to access zope as apache is in port 80

You should configure PCGI supplied with Zope (or FastCGI) with your Apache. In this case you will be able to access Zope via Apache, and you do not have to use port 8080. NM